The consumption of omega-3 fatty acids from fish has been associated with numerous benefits, including support for cardiovascular, neurological, ocular, joint and skin health. One of the mechanisms by which omega-3 fatty acids may be functioning is by maintaining healthy inflammatory processes. Eicosapentaenoic acid (EPA), one of the major fatty acids present in fish oil, is a precursor for prostaglandins E1 and E3 as well as the series 5 leukotrienes. Consumption of omega-6 fatty acids tends to favor the production of series 2 prostanoids and series 4 leukotrienes. Maintaining a healthy balance between these different prostanoids and leukotrienes can help support healthy immune function. Specifically, studies have shown that EPA and DHA may play an important role in cardiovascular health. One landmark clinical trial, the GISSI-Prevenzione Trial, involved over 11,000 people and reported that those subjects that received fish oil supplementation experienced significant benefits with respect to cardiovscular health. Docosahexaenoic acid (DHA), the other major omega-3 fatty acid found in fish oil is essential for neurological and visual development and is vital throughout pregnancy to support fetal brain growth and the proper formation of the retina and visual cortex. Supplementation with fish oil may also help support emotional well-being and mood.