SAM-e (S-adenosyl-methionine) is a naturally occurring molecule derived from the amino acid methionine. SAM-e has been shown to be efficacious in supporting numerous aspects of health. SAM-e, as a methyl donor, participates in a wide variety of biochemical reactions, acts as a precursor molecule for glutathione and polyamine synthesis, and supports healthy functioning of neurological processes, joints, and the liver. SAM-e is a methyl donor in the methylation reactions shown to form monoamine neurotransmitters such as dopamine, serotonin and norepinephrine. Human studies show SAM-e supports a positive mood and healthy central nervous system function. SAM-e is also essential to the development of the phospholipid bilayer that makes up the outer membranes of normal cells by contributing to phosphatidylcholine production and cellular membrane fluidity and integrity. SAM-e’s joint support lies not only in its ability to help regulate the body™s normal physiological processes, but also on its putative participation in proteoglycan synthesis and joint cartilage synthesis. SAM-e is thought to function physiologically as a signal of sulfur availability. Some suggest that supplemental S-adenosyl-methionine may compensate for the decreased SAM-e levels in chondrocytes induced by the cytokine interleukin-1, and thus upregulate the chondrocyte’s synthesis of joint proteoglycans. A randomized control study of 56 participants taking SAM-e offered statistically significant results for joint comfort. As a liver health compound, SAM-e has been shown to support the body’s response to adverse biochemical alterations induced by lead and/or alcohol exposure. SAM-e can be an integral part of a liver support regimen by supporting glutathione levels. Human studies indicate that SAM-e supplementation enhances glutathione production in hepatic tissue and red blood cells.