Hyaluronic acid (HA) is produced by keratinocytes and is a member of a large family of glycosaminoglycans which are the main components of the extracellular matrix . It is abundant in tissues and fluids with the highest concentrations in synovial fluid, vitreous humor and skin. Studies have revealed that most HA properties depend on its molecular size. Many sources of HA consist of a high molecular weight which is too large to be absorbed in the intestines. HyaMax® sodium hyaluronate provides a low molecular weight source of yaluronic acid produced through a fermentation process . In a pharmacokinetic study, orally administered HyaMax hyaluronic acid was incorporated into joints, connective tissue and skin with a particular affinity for cartilaginous joints.
Synovial fluid of the joints provides shock absorption and lubrication for movement ; as we age this fluid decreases. Supplementation with oral HA has been shown to help retain more synovial fluid and protect the joints , as well as modulate prostaglandin production. It has also been shown to support the skin by promoting healthy turnover and renewal of keratinocytes moderating the appearance of fine lines and age spots.