PureGenomics UltraMultivitamin is designed to support optimal health with a comprehensive profile of bioavailable vitamins, chelated minerals and antioxidants. Specifically, it includes activated B vitamins and more choline to support healthy methylation, which plays many essential roles including neurotransmission, vitamin assimilation, DNA synthesis and gene regulation. These functions maintain cardiovascular function, cognition, emotional wellness and cellular protection. Additional cellular protection support is offered with the antioxidants alpha lipoic acid and CoQ10, as well as N-acetyl-L-cysteine to support endogenous glutathione production. Genetic variations in the SLC23A1 gene are associated with absorption of vitamin C. Folate is offered in this formula as Metafolin 5-methyltetrahydrofolate (5-MTHF), the universally metabolized and biologically active form of folate. The genetic variations MTHFR and PEMT, critical for methylation and the formation of choline, respectively, have been associated with increased choline needs. Vitamin B12 is offered as adenosylcobalamin and hydroxycobalamin, a precursor form of vitamin B12 converted in the body to both methylcobalamin and adenosylcobalamin. Magnesium is provided in this formula in an innovative microencapsulation form designed to enhance absorption. Magnesium and lithium may help support cognitive function and emotional balance in some individuals. Preformed vitamin A is provided along with a blend of lutein and zeaxanthin to promote macular health for individuals with genetic variations in the enzyme BCMO1, which can decrease the conversion efficacy of carotenoids into retinal by up to 69%. Enhanced-absorption diindolylmethane is also included to support healthy estrogen metabolism.